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  • N-free survival (pfs) and overall survival (os) of patients with advanced, unresectable angiosarcoma treated with amg 386. To correlate orr, pfs, and os with: baseline and post-treatment changes in expression of angiopoietin 2 (ang2) and tek tyrosine kinase, endothelial (tie2) by immunohistochemistry (ihc). (exploratory) serum levels of angiopoietin 1 (ang1) and ang2. (exploratory) baseline and post-treatment changes in phospho-receptor tyrosine kinase status of tie2, vascular endothelial growth factor receptor 2 (vegfr-2), phosphatidylinositol 3 kinase (pi3k), mitogen-activated protein kinase inhibitor (mek) in tumor tissue. (exploratory) mutational status of vegfr-2 and amplification of v-myc myelocytomatosis viral oncogene homolog (avian) (myc)/fms-related tyrosine kinase 4 (flt4). (exploratory) outline: this is a multicenter study. Patients receive trebananib iv over 30-60 minutes on days 1, 8, 15, and 22. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. genric viagra online for sale jidoushahoken-guide.jp Patients may undergo blood sample collection at baseline and periodically during treatment for correlative studies. Tumor tissue samples may be also collected. After completion of study treatment, patients are followed up for 4 weeks and then every 6 months for 18 months.   eligibility ages eligible for study:   18 years and older genders eligible for study:   both accepts healthy volunteers:   no criteria disease characteristics: patients must have histologically confirmed angiosarcoma that is unresectable patients must have measurable disease per response evaluation criteria in solid tumors (recist) 1. 1, defined as at least one lesion that can be accurately measured in at least one dimension (longest diameter to be recorded for non-nodal lesions a. Jardin Éternel
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